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    <ns1:ESCellLine>TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]</ns1:ESCellLine>
    <ns1:expectedDelivery xml:lang="ja">C（3〜6か月）</ns1:expectedDelivery>
    <ns1:colonyMaintenance xml:lang="en">Backcross to C57BL/6 (Heterozygote x C57BL/6J)Homozygous deficient mice are viable and fertile.</ns1:colonyMaintenance>
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    <ns6:brs_depositor xml:lang="ja">宮島　篤</ns6:brs_depositor>
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    <ns1:colonyMaintenance xml:lang="en">Backcross to C57BL/6 (Heterozygote x C57BL/6J) Homozygous deficient mice are viable and fertile.</ns1:colonyMaintenance>
    <ns4:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr01491'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns4:addinfo>
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    <ns1:strainDevelopment xml:lang="ja">開発年：2001年 開発者：坂東高功先生、宮島篤先生 機関名：東京大学、分子細胞生物学研究所</ns1:strainDevelopment>
    <ns4:termsAndConditions xml:lang="en">The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Cell Biol., 10, 4160-4175 (2005).The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.</ns4:termsAndConditions>
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    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Approval form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;&lt;A HREF="https://www.iqb.u-tokyo.ac.jp/cytokine/" target="_blank"&gt;Lab HP (Japanese)&lt;/A&gt;</ns4:addinfo>
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    <ns1:colonyMaintenance xml:lang="ja">繁殖効率：A 行動の異常がある</ns1:colonyMaintenance>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_6"/>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_8"/>
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    <ns6:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_3"/>
    <ns4:termsAndConditions xml:lang="ja">条件を付加する。利用者は事前に寄託者の提供承諾書を得る。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。Mol. Cell Biol., 10, 4160-4175 (2005).&lt;br&gt;寄託者の承諾を得る。</ns4:termsAndConditions>
    <ns1:strainDevelopment xml:lang="ja">開発年：2001年開発者：坂東高功先生、宮島篤先生機関名：東京大学、分子細胞生物学研究所</ns1:strainDevelopment>
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    <dcterms:identifier>RBRC01491</dcterms:identifier>
    <ns6:brs_depositor xml:lang="en">Atsushi MIYAJIMA</ns6:brs_depositor>
    <rdfs:label xml:lang="en">B6;B6CB-Lrrn4&lt;tm1&gt;/Rbrc</rdfs:label>
    <ns7:SIO_001279 rdf:parseType="Resource">
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    <skos:altLabel xml:lang="en">NLRR4-KO(B6); B6.Cg-B430119L13Rik&lt;tm&gt;</skos:altLabel>
    <skos:altLabel xml:lang="ja">NLRR4-KO(B6); B6.Cg-B430119L13Rik&lt;tm&gt;</skos:altLabel>
    <ns1:donorDNA>mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, E. coli lacZ, poly A, mouse Lrrn4 genomic DNA</ns1:donorDNA>
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    <ns9:RO_0002162 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
    <ns6:brs_depositorOrganization xml:lang="en">Univ. Tokyo</ns6:brs_depositorOrganization>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_4"/>
    <ns1:colonyMaintenance xml:lang="ja">繁殖効率：A行動の異常がある</ns1:colonyMaintenance>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns1:expectedDelivery xml:lang="en">C (3-6 months)</ns1:expectedDelivery>
    <ns6:brs_depositorOrganization xml:lang="ja">国立大学法人東京大学</ns6:brs_depositorOrganization>
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    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/straintype_14"/>
    <ns1:strainDevelopment xml:lang="en">Developed by Drs. Takayoshi Bando and Atsushi Miyajima at the University of Tokyo in 2001.  The TT2 ES cells originated from an F1 embryo between C57BL/6 and CBA mice were used.  The targeting construct contains relpaced exons with the beta-galactosidase and the neomycin resistance genes by homologous reconbination.  The NLRR4 deficient mice were backcrossed to C57BL/6JJcl.</ns1:strainDevelopment>
    <ns1:genotypingProtocol rdf:resource="http://mus.brc.riken.jp/DataSheet/pcr01491"/>
    <skos:altLabel xml:lang="en">NLRR4-KO(B6); B6.Cg-B430119L13Rik&lt;tm&gt;, B6;B6CB-Lrrn4&lt;tm1&gt;/Rbrc</skos:altLabel>
    <skos:altLabel xml:lang="ja">NLRR4-KO(B6); B6.Cg-B430119L13Rik&lt;tm&gt;, B6;B6CB-Lrrn4&lt;tm1&gt;/Rbrc</skos:altLabel>
    <dc:description xml:lang="en">B6.Cg-B430119L13Rik&lt;tm&gt;.  NLRR4 is a member of the neuronal leucine-rich repeat protein family.  NLRR proteins are type I transmembrane proteins with leucine-rich repeats and a fibronectine type III repeat, and expressed in neuronal tissues.  NLRR4 deficient mice have a severe damage to their long-term memory in hippocampus-dependent tasks, while their hippocampal long-term potentiation was intact.   NLRR4 plays a role in hippocamus-dependent long-lasting memory.</dc:description>
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    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC01491"/>
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/RecoveryTestResult_474">
    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC01491"/>
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    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC01491"/>
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